Your baby may also show symptoms of an infection, such as: apnea, or disrupted breathing lethargy What Causes Necrotizing Enterocolitis? A weakened state makes it easier for bacteria from the food entering the intestine to cause damage to the intestinal tissues. This can lead to the development of an infection or NEC. Other risk factors include having too many red blood cells and having another gastrointestinal condition. Your baby is also at an increased risk for NEC if they were born prematurely.
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Corresponding author. Received Jan 10; Accepted Feb This article has been cited by other articles in PMC. Associated Data Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study. Abstract Necrotizing Enterocolitis NEC is one of the most devastating gastrointestinal diseases in neonates, particularly among preterm infants in whom surgical NEC is the leading cause of morbidity.
NEC pathophysiology occurs in the hyper-reactive milieu of the premature gut after bacterial colonization. The resultant activation of the TLR4 pathway appears to be a strongly contributing factor. Advancements in metagenomics may yield new clarity to the relationship between the neonatal intestinal microbiome and the development of NEC. After a century without effective directed treatments, microbiome manipulation offers a promising therapeutic target for the prevention and treatment of this devastating disease.
Keywords: Neonatal sepsis, Microbiome, Intestinal failure, Prematurity, Inflammation Background Worldwide, sepsis is the third leading cause of neonatal mortality Hansen et al. Necrotizing Enterocolitis NEC is one of the most devastating gastrointestinal diseases in neonates, particularly among preterm infants in whom surgical NEC is the leading cause of morbidity Carter and Holditch-Davis NEC is characterized by submucosal edema and hemorrhage, infiltration of the intestinal wall by neutrophils, disruption of the intestinal villus architecture, and in severe cases, full thickness necrosis or intestinal wall perforation Papillon et al.
Classic early clinical signs of the disease include abdominal distension, feeding intolerance, and bloody stool in infants around 1 week old.
Enterocolitis necrotizante en el recién nacido
Rx: Ileo moderado. Eritema y edema de pared, indicativa de peritonitis. Medir siempre el intestino resecado y el remanente, a fin de planificar el manejo postoperatorio. Construir estomas, evitando anastomosis, por riesgo de dehiscencia postoperatoria. Los resultados a largo plazo no son reportados con frecuencia. En: Oldham KT et al. Surgery of infants and children.
Qué es la enterocolitis necrosante y sus causas
Neonatal intestinal dysbiosis in necrotizing enterocolitis